ABSTRACT. – Large quantities of pesticides were used in Egypt between 1950 and 1981 to secure protection of different crops against insects, pests and weeds; and to fight domestic insects and mosquitoes. Up to 90 % of the agricultural pesticides applied to control different agricultural pathogenic organisms cannot reach their destination and persist in soil for decades, infiltrate into aquatic environments and penetrate aquatic food chain, resulting in serious disadvantages to aquatic habitats and accumulate into food chains decades after their application, causing serious damage to human beings. The results of this study indicate that organochlorine pesticides (OCPs) were found in agricultural drainage water at Kafr El-Sheikh governorate, Egypt, with different concentrations. Numerous bacteria were found to be significantly able to degrade different pesticide compounds. Bacillus cereus and Pseudomonas putida were isolated from agricultural drainage water and proved to be involved in the degradation of OCPs.